| Medical Degree: |
M.D., University of Pennsylvania
|
|---|
| Degree: |
Ph.D., University of Pennsylvania
B.A., Pomona College
|
|---|
| Medical Board Certification: |
Ophthalmology, American Board of Ophthalmology
Ophthalmology, American Board of Ophthalmology, 1987
|
|---|
| Academic Experience: |
Professor, David Geffen School of Medicine - UCLA
Fellowship, Moorfields Eye Hospital
|
|---|
|
|
|
|
|
Bsic and Clinical Research Studies
Basic Research Studies
Biological Basis of Ocular Pain and Photophobia
Our laboratory is dedicated to the study of the neurologic pathways and receptors that are key in the perception of pain in the eye, particularly in response to light. We are using a combination of animal models of genetic conditions that cause sustained light sensitivity (photophobia) in humans to investigate potential mechanisms of action and possible targets for therapy. The laboratory employs a combination of behavioral, neural tracing, molecular genetic strategies, as well as immunohistochemistry and gene expression methods to investigate these conditions.
Investigators
Michael B. Gorin, MD, PhD
Anna Matynia, PhD
Molecular Genetics of Human Eye Disorders
Our laboratory employs standard technologies for the localization of disease-causing genes in families using linkage analysis as well as candidate gene testing by expression studies and mutation-detection by sequencing.
Investigators
Michael B. Gorin, MD, PhD
Anna Matynia, PhD
Ariadna Martinez, MS, MS, CGC
Clinical Research Studies
Genetics of Age-related Maculopathy (GARM)
We are participating in a multicenter study with University of Pittsburgh to understand the genetic and environmental risks that contribute to age-related maculopathy (ARM), one of the leading causes of irreversible blindness in the United States and other industrialized nations. The study is designed to identify genes that alter susceptibility to ARM and determine the extent to which variants in these genes and other factors affect one's risk of developing the condition. Findings may lead to the development of therapeutic and preventive strategies as well as to help individuals determine their future risk of developing ARM. Study candidates include patients with macular degeneration and their children (>49 years old), as well as the spouses or partners of these children, and additional family members of ARM patients.
Investigators
Michael B. Gorin, MD, PhD
Maria Carolina Ortube, MD
Robert Ferrell, PhD
Daniel Weeks, PhD
Yvette Conley, PhD
Rapid, Non-Invasive, Regional Functional Imaging of the Retina
The Institute is participating in a study funded by the National Institutes of Health to monitor the responses of the pupil to light as a method for detecting regional losses of function of the retina.
Because diabetics develop damage initially to certain parts of the retina before they have more serious damage, the ultimate goal of this research is to develop a simple, noninvasive, rapid method for widespread screening of diabetics in order to identify those who may require medical attention and/or therapy for diabetic retinopathy. The risks from this study are minimal. The basic device used for monitoring the eye positions and pupil changes is commercially available and uses invisible levels of light to measure the eye.
The instrument has been constructed by Neuro Kinetics Inc., a company that has licensed this technology from the University of Pittsburgh, which holds the patent on the design and use of this instrument with Dr. Gorin listed as the primary inventor. (Dr. Gorin has a financial interest in this research.)
Investigators
Michael B. Gorin, MD, PhD
Alex Kiderman, PhD
Maria Carolina Ortube, MD
Genetic Studies in Inherited Ocular Disorders
There is a large number of inherited eye disorders that predispose individuals and their families to develop a condition that would impair their vision moderately or severely at birth or later in life. Some of those disorders can also affect the physical appearance of their eyes or they can be part of a more complex syndrome. Identifying the genes and alterations that cause those disorders will aid in the diagnosis, counseling, treatment and possible prevention of such conditions. Diagnosis of presence or absence of the condition in other members of a family can help to find the causative genetic alteration, as well as to understand the clinical variability that can be caused by a common genetic change. Part of our research is to understand the clinical characteristics of these conditions so that we can better diagnosis them in patients and recognize subtle changes in their effects on the eye and vision. Many of these molecular diagnostic tests are unable to find all of the variations that can cause a specific eye condition and there is an ongoing need for research to find the additional genes and causative variants.
Investigators
Anthony J. Aldave, MD
Michael B. Gorin, MD, PhD
Maria Carolina Ortube, MD
Ariadna Martinez, MS, MS CGC
Clinical Characterization, Genetic Testing, and Visual Function in Patients with Stargardt Disease
The primary goal of this study is to perform a comprehensive analysis of visual function in patients diagnosed with Stargardt disease. Stargardt disease is an early onset form of macular degeneration caused by a number of mutations in the abcr gene. Before a treatment trial can proceed, baseline measures defining a broad range of functional parameters, must be obtained in order to evaluate the efficacy of treatment. Molecular genetic testing is being performed to confirm the Stargardt diagnosis and better understand the diversity of the condition. Our goal in this study is to obtain all necessary baseline measures of visual function with a battery of established clinical electrodiagnostic and behavioral tests, to correlate these physiological parameters with specific genetic mutations, and to establish which diagnostic tests can provide the most reliable measures of retinal dysfunction and retinal cell death (atrophy). No treatment will be administered as part of this protocol.
Investigators
Michael B. Gorin, MD, PhD
Steven Nusinowitz, Ph.D.
Debora Farber, PhD
Maria Carolina Ortube, MD
Ariadna Martinez, MS, MS, CGC
Comparison of Methods to Detect Early Retinal Changes that can be associated with Hydroxychloroquine (Plaquenil) Exposure (to start June 2008)
Hydroxychloroquine (Plaquenil) is an oral medication commonly used in the treatment of several chronic autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, and Sjögren syndrome. Patients taking Plaquenil are frequently sent to an eye doctor to be monitored for possible effects of the medication, in particular on the part of the eye called the retina, which is the light sensitive layer at the back of the eye. Plaquenil has been found to cause retinal damage in a small number of individuals, but most people can take the medication for years at normal dosages without any damage to the eye or their sight. Because of the reports of irreversible retinal damage in a small group of patients, screening for Plaquenil-related retinal toxicity is still considered by many to be an important part of patient management. However, there is considerable debate as to which tests provide the most sensitive and specific detection of early retinal changes that may beindicative of damage from this medication. Over the past 15 years, we have seen many patients who are taking Plaquenil and have assessed their visual function using one or more diagnostic tests and many have had repeated annual testing. This study is intended to review the existing data from many of those individuals who had some or all of their testing done at the JSEI Visual Physiology Laboratory to assess the reproducibility of results obtained from these various tests and, more importantly, to determine which tests have a higher degree of sensitivity to detect early retinal changes that might reflect an toxic response to Plaquenil therapy.
Investigators
Michael B. Gorin, MD, PhD
Steven Nusinowitz, Ph.D.
Maria Carolina Ortube, MD
Ariadna Martinez, MS, MS, CGC
Lisa Blasco
Genetics of Postoperative Cystoid Macular Edema (CME) (to start July 2009)
The objectives of this clinical investigation are to (1) determine the incidence of postoperative cystoid macular edema (CME) in uncomplicated small-incision phacoemulsification cataract surgery based on high-resolution optical coherence tomography (OCT)-defined macular swelling, and (2) undertake a genome-wide association study comparing the subjects who develop OCT-defined CME to subjects who do not develop CME.
Investigators
Kevin M. Miller, MD
Michael B. Gorin, MD, PhD
Michael D. Olson, OD, PhD
Maria Carolina Ortube, MD
Ariadna Martinez, MS, MS,CGC
|
Michael B. Gorin, MD, PhD, is the currently the first recipient of the Harold and Pauline Price Chair in Ophthalmology and Professor of Ophthalmology in the Retina and Vision Science Divisions in the Department of Ophthalmology at the David Geffen School of Medicine – UCLA and Jules Stein Eye Institute. He also holds an appointment in the Vision Research Division at the Jules Stein Eye Institute.
Dr. Gorin obtained his medical and doctor of philosophy degrees from the University of Pennsylvania at Philadelphia and completed his internship at the Center for Health Sciences at the University of California at Los Angeles (UCLA). He stayed on at UCLA for postdoctoral research fellowship and ophthalmology residency training at the Jules Stein Eye Institute, and then finished a clinical fellowship in Medical Retina and Genetics at Moorfields Eye Hospital in London, England.
Dr. Gorin returned to UCLA from the University of Pittsburgh, where he served as Assistant Vice Chancellor for Strategic Initiatives for the six graduate health sciences schools. He joined the Pittsburgh campus in 1990, rising to the rank of Professor in the Department of Ophthalmology in the School of Medicine and the Department of Human Genetics in the Graduate School of Public Health and serving as interim chair for both departments. He was founding director of the Center for Human Genetics and a founding senior associate of the Center for Biomedical Informatics at the University. Throughout his 16 years in Pittsburgh, he has provided clinical care on a regular basis in medical retina particularly in the fields of hereditary disorders, retinal diagnostics, drug-related ocular toxicity, and ophthalmic genetics. During 2005-2007, he was named one of the top physicians in the United States by Castle Connolly Medical Ltd.
As a full-time faculty member at the Jules Stein Eye Institute, Dr. Gorin divides his time between patient care for diseases of the retina, research into the genetics of inherited eye disorders and training young ophthalmologists and medical students.
|
|
|
|
Thiels, E. Hoffman, E. K. Gorin, M. B. A reliable behavioral assay for the assessment of sustained photophobia in mice.
Curr Eye Res.
2008; 33( 5):
483-91.
Jakobsdottir, J. Conley, Y. P. Weeks, D. E. Ferrell, R. E. Gorin, M. B. C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes.
PLoS ONE.
2008; 3( 5):
e2199.
Gorin, M. B. A clinician's view of the molecular genetics of age-related maculopathy.
Arch Ophthalmol.
2007; 125( 1):
21-9.
Ghajarnia, M. Gorin, M. B. Acetazolamide in the treatment of X-linked retinoschisis maculopathy.
Arch Ophthalmol.
2007; 125( 4):
571-3.
Tikellis, G. Sun, C. Gorin, M. B. Klein, R. Klein, B. E. Larsen, E. K. Siscovick, D. S. Hubbard, L. D. Wong, T. Y. Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study.
Arch Ophthalmol.
2007; 125( 1):
68-73.
Young, T. A. Burgess, B. L. Rao, N. P. Gorin, M. B. Straatsma, B. R. High-density genome array is superior to fluorescence in-situ hybridization analysis of monosomy 3 in choroidal melanoma fine needle aspiration biopsy.
Mol Vis.
2007; 13(number):
2328-33.
Thomas, G. Grassi, M. A. Lee, J. R. Edwards, A. O. Gorin, M. B. Klein, R. Casavant, T. L. Scheetz, T. E. Stone, E. M. Williams, A. B. IDOCS: intelligent distributed ontology consensus system--the use of machine learning in retinal drusen phenotyping.
Invest Ophthalmol Vis Sci.
2007; 48( 5):
2278-84.
Yellore, V. S. Khan, M. A. Bourla, N. Rayner, S. A. Chen, M. C. Sonmez, B. Momi, R. S. Sampat, K. M. Gorin, M. B. Aldave, A. J. Identification of mutations in UBIAD1 following exclusion of coding mutations in the chromosome 1p36 locus for Schnyder crystalline corneal dystrophy.
Mol Vis.
2007; 13(number):
1777-82.
Finn, D. A. Beadles-Bohling, A. S. Beckley, E. H. Ford, M. M. Gililland, K. R. Gorin-Meyer, R. E. Wiren, K. M. A new look at the 5alpha-reductase inhibitor finasteride.
CNS Drug Rev.
2006; 12( 1):
53-76.
Demirci, F. Y. Rigatti, B. W. Mah, T. S. Gorin, M. B. A novel RPGR exon ORF15 mutation in a family with X-linked retinitis pigmentosa and Coats'-like exudative vasculopathy.
Am J Ophthalmol.
2006; 141( 1):
208-10.
Demirci, F. Y. Chang, M. H. Mah, T. S. Romero, M. F. Gorin, M. B. Proximal renal tubular acidosis and ocular pathology: a novel missense mutation in the gene (SLC4A4) for sodium bicarbonate cotransporter protein (NBCe1).
Mol Vis.
2006; 12(number):
324-30.
Gorin, M. B. A new vision for age-related macular degeneration.
Eur J Hum Genet.
2005; 13( 7):
793-4.
Demirci, F. Y. Gupta, N. Radak, A. L. Rigatti, B. W. Mah, T. S. Milam, A. H. Gorin, M. B. Histopathologic study of X-linked cone-rod dystrophy (CORDX1) caused by a mutation in the RPGR exon ORF15.
Am J Ophthalmol.
2005; 139( 2):
386-8.
Gorin, M. B. Costantino, J. P. Kulacoglu, D. N. Demirci, F. Y. Wickerham, D. L. Fisher, B. Wolmark, N. Is tamoxifen a risk factor for retinal vaso-occlusive disease?.
Retina.
2005; 25( 4):
523-6.
Jakobsdottir, J. Conley, Y. P. Weeks, D. E. Mah, T. S. Ferrell, R. E. Gorin, M. B. Susceptibility genes for age-related maculopathy on chromosome 10q26.
Am J Hum Genet.
2005; 77( 3):
389-407.
Gorin, M. B. The coming of age for age-related macular degeneration genetics.
Ophthalmic Genet.
2005; 26( 2):
57-9.
Demirci, F. Y. Rigatti, B. W. Mah, T. S. Gorin, M. B. A novel compound heterozygous mutation in the cellular retinaldehyde-binding protein gene (RLBP1) in a patient with retinitis punctata albescens.
Am J Ophthalmol.
2004; 138( 1):
171-3.
Demirci, F. Y. Radak, A. L. Rigatti, B. W. Mah, T. S. Gorin, M. B. A presumed missense mutation of RPGR causes abnormal RNA splicing with exon skipping.
Am J Ophthalmol.
2004; 138( 3):
504-5.
Weeks, D. E. Conley, Y. P. Tsai, H. J. Mah, T. S. Schmidt, S. Postel, E. A. Agarwal, A. Haines, J. L. Pericak-Vance, M. A. Rosenfeld, P. J. Paul, T. O. Eller, A. W. Morse, L. S. Dailey, J. P. Ferrell, R. E. Gorin, M. B. Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions.
Am J Hum Genet.
2004; 75( 2):
174-89.
Jalkanen, R. Demirci, F. Y. Tyynismaa, H. Bech-Hansen, T. Meindl, A. Peippo, M. Mantyjarvi, M. Gorin, M. B. Alitalo, T. A new genetic locus for X linked progressive cone-rod dystrophy.
J Med Genet.
2003; 40( 6):
418-23.
Telmer, C. A. Retchless, A. C. Kinsey, A. D. Conley, Y. Rigatti, B. Gorin, M. B. Jarvik, J. W. Detection and assignment of mutations and minihaplotypes in human DNA using peptide mass signature genotyping (PMSG): application to the human RDS/peripherin gene.
Genome Res.
2003; 13( 8):
1944-51.
Demirci, F. Y. Ramser, J. White, N. J. Rigatti, B. W. Meindl, A. Lewis, K. F. Wen, G. Gorin, M. B. Refinement of the physical location and the genomic characterization of the CRSP2 (EXLM1) gene on Xp11.4.
DNA Seq.
2003; 14( 2):
123-7.
Conley, Y. P. Gorin, M. B. The genetics of age-related macular degeneration.
Medsurg Nurs.
2003; 12( 4):
238-41, 259.
Schmidt, S. Klaver, C. Saunders, A. Postel, E. De La Paz, M. Agarwal, A. Small, K. Udar, N. Ong, J. Chalukya, M. Nesburn, A. Kenney, C. Domurath, R. Hogan, M. Mah, T. Conley, Y. Ferrell, R. Weeks, D. de Jong, P. T. van Duijn, C. Haines, J. Pericak-Vance, M. Gorin, M. A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy.
Ophthalmic Genet.
2002; 23( 4):
209-23.
Weeks, D. E. Conley, Y. P. Ferrell, R. E. Mah, T. S. Gorin, M. B. A tale of two genotypes: consistency between two high-throughput genotyping centers.
Genome Res.
2002; 12( 3):
430-5.
Gordon, Y. J. Mann, R. K. Mah, T. S. Gorin, M. B. Fluorescein-potentiated argon laser therapy improves symptoms and appearance of corneal neovascularization.
Cornea.
2002; 21( 8):
770-3.
Demirci, F. Y. Rigatti, B. W. Wen, G. Radak, A. L. Mah, T. S. Baic, C. L. Traboulsi, E. I. Alitalo, T. Ramser, J. Gorin, M. B. X-linked cone-rod dystrophy (locus COD1): identification of mutations in RPGR exon ORF15.
Am J Hum Genet.
2002; 70( 4):
1049-53.
Ayyagari, R. Demirci, F. Y. Liu, J. Bingham, E. L. Stringham, H. Kakuk, L. E. Boehnke, M. Gorin, M. B. Richards, J. E. Sieving, P. A. X-linked recessive atrophic macular degeneration from RPGR mutation.
Genomics.
2002; 80( 2):
166-71.
Weeks, D. E. Conley, Y. P. Tsai, H. J. Mah, T. S. Rosenfeld, P. J. Paul, T. O. Eller, A. W. Morse, L. S. Dailey, J. P. Ferrell, R. E. Gorin, M. B. Age-related maculopathy: an expanded genome-wide scan with evidence of susceptibility loci within the 1q31 and 17q25 regions.
Am J Ophthalmol.
2001; 132( 5):
682-92.
Milam, A. H. De Castro, E. B. Smith, J. E. Tang, W. X. John, S. K. Gorin, M. B. Stone, E. M. Aguirre, G. D. Jacobson, S. G. Concentric retinitis pigmentosa: clinicopathologic correlations.
Exp Eye Res.
2001; 73( 4):
493-508.
Gorin, M. B. The ABCA4 gene and age-related macular degeneration: innocence or guilt by association.
Arch Ophthalmol.
2001; 119( 5):
752-3.
Conley, Y. P. Erturk, D. Keverline, A. Mah, T. S. Keravala, A. Barnes, L. R. Bruchis, A. Hess, J. F. FitzGerald, P. G. Weeks, D. E. Ferrell, R. E. Gorin, M. B. A juvenile-onset, progressive cataract locus on chromosome 3q21-q22 is associated with a missense mutation in the beaded filament structural protein-2.
Am J Hum Genet.
2000; 66( 4):
1426-31.
Kniazeva, M. Traboulsi, E. I. Yu, Z. Stefko, S. T. Gorin, M. B. Shugart, Y. Y. O'Connell, J. R. Blaschak, C. J. Cutting, G. Han, M. Zhang, K. A new locus for dominant drusen and macular degeneration maps to chromosome 6q14.
Am J Ophthalmol.
2000; 130( 2):
197-202.
Brown, J., Jr. Kimura, A. E. Gorin, M. B. Clinical and electroretinographic findings of female carriers and affected males in a progressive X-linked cone-rod dystrophy (COD-1) pedigree.
Ophthalmology.
2000; 107( 6):
1104-10.
Stefko, S. T. Zhang, K. Gorin, M. B. Traboulsi, E. I. Clinical spectrum of chromosome 6-linked autosomal dominant drusen and macular degeneration.
Am J Ophthalmol.
2000; 130( 2):
203-8.
Hardcastle, A. J. Thiselton, D. L. Zito, I. Ebenezer, N. Mah, T. S. Gorin, M. B. Bhattacharya, S. S. Evidence for a new locus for X-linked retinitis pigmentosa (RP23).
Invest Ophthalmol Vis Sci.
2000; 41( 8):
2080-6.
Pieke-Dahl, S. Moller, C. G. Kelley, P. M. Astuto, L. M. Cremers, C. W. Gorin, M. B. Kimberling, W. J. Genetic heterogeneity of Usher syndrome type II: localisation to chromosome 5q.
J Med Genet.
2000; 37( 4):
256-62.
Astuto, L. M. Weston, M. D. Carney, C. A. Hoover, D. M. Cremers, C. W. Wagenaar, M. Moller, C. Smith, R. J. Pieke-Dahl, S. Greenberg, J. Ramesar, R. Jacobson, S. G. Ayuso, C. Heckenlively, J. R. Tamayo, M. Gorin, M. B. Reardon, W. Kimberling, W. J. Genetic heterogeneity of Usher syndrome: analysis of 151 families with Usher type I.
Am J Hum Genet.
2000; 67( 6):
1569-74.
Zito, I. Gorin, M. B. Plant, C. Bird, A. C. Bhattacharya, S. S. Hardcastle, A. J. Novel mutations of the RPGR gene in RP3 families.
Hum Mutat.
2000; 15( 4):
386.
Zito, I. Thiselton, D. L. Gorin, M. B. Stout, J. T. Plant, C. Bird, A. C. Bhattacharya, S. S. Hardcastle, A. J. Identification of novel RPGR (retinitis pigmentosa GTPase regulator) mutations in a subset of X-linked retinitis pigmentosa families segregating with the RP3 locus.
Hum Genet.
1999; 105( 1-2):
57-62.
Feng, L. Seymour, A. B. Jiang, S. To, A. Peden, A. A. Novak, E. K. Zhen, L. Rusiniak, M. E. Eicher, E. M. Robinson, M. S. Gorin, M. B. Swank, R. T. The beta3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness.
Hum Mol Genet.
1999; 8( 2):
323-30.
Keverline, M. R. Mah, T. S. Keverline, P. O. Gorin, M. B. A practice-based survey of familial age-related maculopathy.
Ophthalmic Genet.
1998; 19( 1):
19-26.
Seymour, A. B. Dash-Modi, A. O'Connell, J. R. Shaffer-Gordon, M. Mah, T. S. Stefko, S. T. Nagaraja, R. Brown, J. Kimura, A. E. Ferrell, R. E. Gorin, M. B. Linkage analysis of X-linked cone-rod dystrophy: localization to Xp11.4 and definition of a locus distinct from RP2 and RP3.
Am J Hum Genet.
1998; 62( 1):
122-9.
Gorin, M. B. Day, R. Costantino, J. P. Fisher, B. Redmond, C. K. Wickerham, L. Gomolin, J. E. Margolese, R. G. Mathen, M. K. Bowman, D. M. Kaufman, D. I. Dimitrov, N. V. Singerman, L. J. Bornstein, R. Wolmark, N. Long-term tamoxifen citrate use and potential ocular toxicity.
Am J Ophthalmol.
1998; 125( 4):
493-501.
Andersen, J. S. Pralea, A. M. DelBono, E. A. Haines, J. L. Gorin, M. B. Schuman, J. S. Mattox, C. G. Wiggs, J. L. A gene responsible for the pigment dispersion syndrome maps to chromosome 7q35-q36.
Arch Ophthalmol.
1997; 115( 3):
384-8.
Seymour, A. B. Yanak, B. L. O'Brien, E. P. Rusiniak, M. E. Novak, E. K. Pinto, L. H. Swank, R. T. Gorin, M. B. An integrated genetic map of the pearl locus of mouse chromosome 13.
Genome Res.
1996; 6( 6):
538-44.
Weston, M. D. Kelley, P. M. Overbeck, L. D. Wagenaar, M. Orten, D. J. Hasson, T. Chen, Z. Y. Corey, D. Mooseker, M. Sumegi, J. Cremers, C. Moller, C. Jacobson, S. G. Gorin, M. B. Kimberling, W. J. Myosin VIIA mutation screening in 189 Usher syndrome type 1 patients.
Am J Hum Genet.
1996; 59( 5):
1074-83.
Xu, H. P. Yanak, B. L. Wigler, M. H. Gorin, M. B. New polymorphic markers in the vicinity of the pearl locus on mouse chromosome 13.
Mamm Genome.
1996; 7( 1):
16-9.
Ip, M. Gorin, M. B. Recurrence of a choroidal neovascular membrane in a patient with punctate inner choroidopathy treated with daily doses of thalidomide.
Am J Ophthalmol.
1996; 122( 4):
594-5.
Nayfield, S. G. Gorin, M. B. Tamoxifen-associated eye disease. A review.
J Clin Oncol.
1996; 14( 3):
1018-26.
Gorin, M. B. Jackson, K. E. Ferrell, R. E. Sheffield, V. C. Jacobson, S. G. Gass, J. D. Mitchell, E. Stone, E. M. A peripherin/retinal degeneration slow mutation (Pro-210-Arg) associated with macular and peripheral retinal degeneration.
Ophthalmology.
1995; 102( 2):
246-55.
Day, R. Gorin, M. B. Eller, A. W. Prevalence of lens changes in Ukrainian children residing around Chernobyl.
Health Phys.
1995; 68( 5):
632-42.
Parker, L. S. Gorin, M. B. Preventive ethics in the management of ophthalmic genetic disorders.
Semin Ophthalmol.
1995; 10( 4):
331-43.
Gorin, M. B. The interplay of genetics and surgery in ophthalmic care.
Semin Ophthalmol.
1995; 10( 4):
303-17.
Gorin, M. B. Paul, T. O. Rader, D. J. Angioid streaks associated with abetalipoproteinemia.
Ophthalmic Genet.
1994; 15( 3-4):
151-9.
Hong, H. K. Ferrell, R. E. Gorin, M. B. Clinical diversity and chromosomal localization of X-linked cone dystrophy (COD1).
Am J Hum Genet.
1994; 55( 6):
1173-81.
Brown, D. L. Gorin, M. B. Weeks, D. E. Efficient strategies for genomic searching using the affected-pedigree-member method of linkage analysis.
Am J Hum Genet.
1994; 54( 3):
544-52.
Donahue, S. P. Wenger, S. L. Steele, M. W. Gorin, M. B. Broad-spectrum Mobius syndrome associated with a 1;11 chromosome translocation.
Ophthalmic Paediatr Genet.
1993; 14( 1):
17-21.
Pieke Dahl, S. Kimberling, W. J. Gorin, M. B. Weston, M. D. Furman, J. M. Pikus, A. Moller, C. Genetic heterogeneity of Usher syndrome type II.
J Med Genet.
1993; 30( 10):
843-8.
Rikke, B. A. Pinto, L. H. Gorin, M. B. Hardies, S. C. Mus spretus-specific LINE-1 DNA probes applied to the cloning of the murine pearl locus.
Genomics.
1993; 15( 2):
291-6.
Gorin, M. B. Snyder, S. To, A. Narfstrom, K. Curtis, R. The cat RDS transcript: candidate gene analysis and phylogenetic sequence analysis.
Mamm Genome.
1993; 4( 9):
544-8.
Filling-Katz, M. R. Fink, J. K. Gorin, M. B. Caruso, R. Carl, J. B. Fitzgibbon, E. J. Barton, N. W. Katz, N. N. Ophthalmologic manifestations of type B Niemann-Pick diseases.
Metab Pediatr Syst Ophthalmol.
1992; 15( 1-3):
16-20.
Gorin, M. B. Von Hippel-Lindau disease: clinical considerations and the use of fluorescein-potentiated argon laser therapy for treatment of retinal angiomas.
Semin Ophthalmol.
1992; 7( 3):
182-91.
Filling-Katz, M. R. Choyke, P. L. Oldfield, E. Charnas, L. Patronas, N. J. Glenn, G. M. Gorin, M. B. Morgan, J. K. Linehan, W. M. Seizinger, B. R. et al., Central nervous system involvement in Von Hippel-Lindau disease.
Neurology.
1991; 41( 1):
41-6.
Glenn, G. M. Daniel, L. N. Choyke, P. Linehan, W. M. Oldfield, E. Gorin, M. B. Hosoe, S. Latif, F. Weiss, G. Walther, M. et al., Von Hippel-Lindau (VHL) disease: distinct phenotypes suggest more than one mutant allele at the VHL locus.
Hum Genet.
1991; 87( 2):
207-10.
Hosoe, S. Brauch, H. Latif, F. Glenn, G. Daniel, L. Bale, S. Choyke, P. Gorin, M. Oldfield, E. Berman, A. et al., Localization of the von Hippel-Lindau disease gene to a small region of chromosome 3.
Genomics.
1990; 8( 4):
634-40.
Choyke, P. L. Filling-Katz, M. R. Shawker, T. H. Gorin, M. B. Travis, W. D. Chang, R. Seizinger, B. R. Dwyer, A. J. Linehan, W. M. von Hippel-Lindau disease: radiologic screening for visceral manifestations.
Radiology.
1990; 174( 3 Pt 1):
815-20.
Gibbons, I. Gorin, M. Yassinzadeh, Z. Peterson, P. Besemer, D. Dillon, K. Burd, T. Hillman, R. Smoluk, G. Cobb, M. Patient-side immunoassay system with a single-use cartridge for measuring analytes in blood.
Clin Chem.
1989; 35( 9):
1869-73.
Filling-Katz, M. R. Choyke, P. L. Patronas, N. J. Gorin, M. B. Barba, D. Chang, R. Doppman, J. L. Seizinger, B. Oldfield, E. H. Radiologic screening for von Hippel-Lindau disease: the role of Gd-DTPA enhanced MR imaging of the CNS.
J Comput Assist Tomogr.
1989; 13( 5):
743-55.
Barrett, D. J. Sparkes, R. S. Gorin, M. B. Bhat, S. P. Spence, M. A. Marazita, M. L. Bateman, J. B. Genetic linkage analysis of autosomal dominant congenital cataracts with lens-specific DNA probes and polymorphic phenotypic markers.
Ophthalmology.
1988; 95( 4):
538-44.
Hogg, D. Gorin, M. B. Heinzmann, C. Zollman, S. Mohandas, T. Klisak, I. Sparkes, R. S. Breitman, M. Tsui, L. C. Horwitz, J. Nucleotide sequence for the cDNA of the bovine beta B2 crystallin and assignment of the orthologous human locus to chromosome 22.
Curr Eye Res.
1987; 6( 11):
1335-42.
Sparkes, R. S. Mohandas, T. Heinzmann, C. Gorin, M. B. Zollman, S. Horwitz, J. Assignment of a human beta-crystallin gene to 17cen-q23.
Hum Genet.
1986; 74( 2):
133-6.
Sparkes, R. S. Mohandas, T. Heinzmann, C. Gorin, M. B. Horwitz, J. Law, M. L. Jones, C. A. Bateman, J. B. The gene for the major intrinsic protein (MIP) of the ocular lens is assigned to human chromosome 12cen-q14.
Invest Ophthalmol Vis Sci.
1986; 27( 9):
1351-4.
Gorin, M. B. Horwitz, J. Cloning and characterization of a cow beta crystallin cDNA.
Curr Eye Res.
1984; 3( 7):
939-48.
Gorin, M. B. Yancey, S. B. Cline, J. Revel, J. P. Horwitz, J. The major intrinsic protein (MIP) of the bovine lens fiber membrane: characterization and structure based on cDNA cloning.
Cell.
1984; 39( 1):
49-59.
Gorin, M. B. Tilghman, S. M. Structure of the alpha-fetoprotein gene in the mouse.
Proc Natl Acad Sci U S A.
1980; 77( 3):
1351-5.
Hansch, C. Nakamoto, K. Gorin, M. Denisevich, P. Garret, E. R. Heman-Ackah, S. M. Won, C. H. Structure-activity relationship of chloramphenicols.
J Med Chem.
1973; 16( 8):
917-22.
Demirci, F. Y. White, N. J. Rigatti, B. W. Lewis, K. F. Gorin, M. B. Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4).
Mol Vis.
2001; 7(number):
234-9.
Feng, L. Rigatti, B. W. Novak, E. K. Gorin, M. B. Swank, R. T. Genomic structure of the mouse Ap3b1 gene in normal and pearl mice.
Genomics.
2000; 69( 3):
370-9.
Weeks, D. E. Conley, Y. P. Mah, T. S. Paul, T. O. Morse, L. Ngo-Chang, J. Dailey, J. P. Ferrell, R. E. Gorin, M. B. A full genome scan for age-related maculopathy.
Hum Mol Genet.
2000; 9( 9):
1329-49.
Gorin, M. B. Breitner, J. C. De Jong, P. T. Hageman, G. S. Klaver, C. C. Kuehn, M. H. Seddon, J. M. The genetics of age-related macular degeneration.
Mol Vis.
1999; 5(number):
29.
Zhen, L. Jiang, S. Feng, L. Bright, N. A. Peden, A. A. Seymour, A. B. Novak, E. K. Elliott, R. Gorin, M. B. Robinson, M. S. Swank, R. T. Abnormal expression and subcellular distribution of subunit proteins of the AP-3 adaptor complex lead to platelet storage pool deficiency in the pearl mouse.
Blood.
1999; 94( 1):
146-55.
Nwokoro, N. A. Korytkowski, M. T. Rose, S. Gorin, M. B. Penles Stadler, M. Witchel, S. F. Mulvihill, J. J. Spectrum of malignancy and premalignancy in Carney syndrome.
Am J Med Genet.
1997; 73( 4):
369-77.
Gorin, M. B. To, A. C. Narfstrom, K. Sequence analysis and exclusion of phosducin as the gene for the recessive retinal degeneration of the Abyssinian cat.
Biochim Biophys Acta.
1995; 1260( 3):
323-7.
Sigman, D. S. Chen, C. H. Gorin, M. B. Sequence-specific scission of DNA by RNAs linked to a chemical nuclease.
Nature.
1993; 363( 6428):
474-5.
Chen, C. B. Gorin, M. B. Sigman, D. S. Sequence-specific scission of DNA by the chemical nuclease activity of 1,10-phenanthroline-copper(I) targeted by RNA.
Proc Natl Acad Sci U S A.
1993; 90( 9):
4206-10.
Glenn, G. M. Linehan, W. M. Hosoe, S. Latif, F. Yao, M. Choyke, P. Gorin, M. B. Chew, E. Olfield, E. Manolatos, C. et al., Screening for von Hippel-Lindau disease by DNA polymorphism analysis.
JAMA.
1992; 267( 9):
1226-31.
Arden, G. B. Gorin, M. B. Polkinghorne, P. J. Jay, M. Bird, A. C. Detection of the carrier state of X-linked retinoschisis.
Am J Ophthalmol.
1988; 105( 6):
590-5.
Hogg, D. Tsui, L. C. Gorin, M. Breitman, M. L. Characterization of the human beta-crystallin gene Hu beta A3/A1 reveals ancestral relationships among the beta gamma-crystallin superfamily.
J Biol Chem.
1986; 261( 26):
12420-7.
Gorin, M. B. Cooper, D. L. Eiferman, F. van de Rijn, P. Tilghman, S. M. The evolution of alpha-fetoprotein and albumin. I. A comparison of the primary amino acid sequences of mammalian alpha-fetoprotein and albumin.
J Biol Chem.
1981; 256( 4):
1954-9.
Kioussis, D. Eiferman, F. van de Rijn, P. Gorin, M. B. Ingram, R. S. Tilghman, S. M. The evolution of alpha-fetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse.
J Biol Chem.
1981; 256( 4):
1960-7.
Tilghman, S. M. Kioussis, D. Gorin, M. B. Ruiz, J. P. Ingram, R. S. The presence of intervening sequences in the alpha-fetoprotein gene of the mouse.
J Biol Chem.
1979; 254( 15):
7393-9.
|
|
|
Disability Resources
